A thorough understanding of the natural history of this entity is of paramount importance to avoid unnecessary and potentially morbid interventions. ĬCM may be diagnosed in both young children and adults and may develop de novo or even regress spontaneously during a patient’s lifetime. CCMs range in size from punctate to several centimeters in diameter and may occur anywhere in the central nervous system with up to 20% located in the brainstem. Adding to the confusion, CCM has assumed a variety of names in the medical literature including cavernomas, cavernous angiomas, and cavernous hemangiomas, though CCM is the preferred nomenclature. Clinically, CCMs are highly variable in both symptomatic presentation and natural history. McCormick (1966) recognized CCMs as one of the four classes of cerebral vascular malformations which include arteriovenous malformations (AVM), developmental venous anomalies (DVA), and capillary telangiectasia. This activity reviews the pathogenesis, diagnosis, evaluation, and treatment of cerebral cavernous malformations and emphasizes the role of the interprofessional team in improving care for patients with this condition.Ĭerebral cavernous malformations (CCMs) are abnormally large collections of "low flow" vascular channels without brain parenchyma intervening between the sinusoidal vessels. Given the heterogeneity of this condition, the ontogenesis, diagnosis, management strategies for CCM are subjects of ongoing debate and treatment paradigms continue to evolve. Thorough knowledge of the natural history of this entity is of paramount importance to avoid unnecessary and potentially morbid interventions. CCM may be diagnosed in both young children and adults and may develop de novo or even regress spontaneously during a patient’s lifetime. CCMs range in diameter from under a millimeter to several centimeters and may occur anywhere in the central nervous system with up to 20 percent located in the brainstem. Adding to the confusion, they are also referred to as cavernomas, cavernous angiomas, and cavernous hemangiomas, though CCM is the preferred nomenclature. Clinically, cerebral cavernous malformations have highly variable presentations. A cerebral cavernous malformation (CCM) is an abnormally large collection of "low flow" vascular channels without brain parenchyma intervening between the sinusoidal vessels.
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